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It is a first-generation antihistamine
It induced tumor regression in mouse xenograft tumor models driven by Bcr-Abl(WT) or the mutants and significantly improved the survival of mice bearing an allograft leukemia model with Ba/F3 cells harboring Bcr-Abl(T315I)
Smiles: OCCOCCN1CCN(CC1)C1=NC2=CC=CC=C2SC2=CC=CC=C21
1093/biolre/iox048
Reversine Catalog No.:M10364-10 It is a first-generation antihistamineReversine is a small molecule developed by the group of Peter G. Schultz, used for stem cell dedifferentiation. Reversine is also a novel Aurora kinases inhibitor that inhibits colony formation of human acute myeloid leukemia cells. Reversine inhibits the phosphorylation of histone H3, a direct downstream target of Aurora kinases. Similarly to the Aurora kinase inhibitor VX 680, reversine inhibited colony formation of leukemic cells from patients with
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